|
rs9841504
|
|
|
0.720 |
GeneticVariation |
GWASDB |
We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)).
|
22037551 |
2011 |
|
rs9841504
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Those subjects with both the risk alleles MUC1 rs9841504 and ZBTB20 rs4072037 had a greater than 3-fold increased risk of gastric cancer.
|
27127881 |
2016 |
|
rs9841504
|
|
|
0.720 |
GeneticVariation |
BEFREE |
However, we found no association between rs9841504 and gastric cancer risk.
|
23861218 |
2013 |
|
rs3747093
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Interestingly, we observed consistent associations between rs3747093 and multiple cancers (gastric cancer: OR = 0.85, P = 2.21 × 10<sup>-4</sup>; esophageal cancer: OR = 0.91, P = 2.57 × 10<sup>-2</sup>; colorectal cancer: OR = 0.80, P = 1.85 × 10<sup>-6</sup>; and breast cancer: OR = 0.87, P = 1.55 × 10<sup>-3</sup>).
|
28653172 |
2017 |
|
rs828907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this hospital-based case-control study of gastric cancer in Jiangsu Province, China, we investigated the association of the Ku80 G-1401T (rs828907) polymorphism with gastric cancer risk.
|
21547134 |
2011 |
|
rs28360071
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigating the associations between polymorphisms of Insertion/Deletion (I/D, rs28360071) in the intron 3 of the XRCC4 and VNTR in the promoter region of the XRCC5 and risk of gastric cancer, the present study was carried out.
|
25527410 |
2015 |
|
rs861528
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, the XRCC3 rs861528 allele A was significantly increased in the patient subgroup with diffuse GC (OR: 1.75; 95% CI: 1.30-2.37).
|
28415781 |
2017 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis aimed to summarize published data about the association between two SNPs of XRCC1 (Arg194Trp and Arg399Gln) and treatment outcomes of patients with advanced gastric cancer.
|
24465544 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that the genetic variant Arg280His in XRCC1 may contribute to cancer progression and that XRCC1 Arg194Trp variants may act as a favorable prognostic indicator of resected GC, particularly among the diffuse-type GC.
|
23425027 |
2013 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, significant associations between Arg194Trp polymorphism and gastric cancer were found in Asian.
|
25335737 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphic variants of base excision repair (APE1-D148E, XRCC1-R194W, XRCC1-R399Q and OGG1-S326C), nucleotide excision repair (XPC-PAT, XPA-23G>A, ERCC1-19007T>C and XPD-L751Q), recombination (XRCC3-T241M) and alkylation damage reversal (MGMT-L84F) were tested for their potential role in the development of GC by using logistic regression models.
|
20817763 |
2010 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase (ADPRT, Val762Ala), 8-oxoguanine DNA glycosylase (OGG1, Ser326Cys) and apurinic/apyrimidinic endonuclease 1 (APE1, Asp148Glu) and evolution of H.pylori-associated precancerous gastric lesions, a population-based cohort study was conducted in Linqu County, a high-risk area of gastric cancer in China.
|
19147860 |
2009 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, XRCC1 Arg194Trp homozygous mutant genotype (Trp/Trp) was found to be associated with increased risk of GC.
|
21604176 |
2012 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we suggest that the XRCC1 gene Arg194Trp polymorphism is associated with gastric cancer susceptibility in the Chinese population.
|
27706710 |
2016 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In particular, individuals with the XRCC1 Arg194Trp variant genotype are at increased risk for GC below 60 years old.
|
23317230 |
2012 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China.
|
22901183 |
2012 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.
|
16425350 |
2005 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis indicates that genetic polymorphism of the XRCC1 Arg399Gln and Arg280His do not have an association with gastric cancer risk.
|
25335737 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that XRCC1 gene rs25487 polymorphism might play a leading role in pronounced susceptibility to gastric cancer in Han Chinese.
|
26590607 |
2016 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No association is found between the XRCC1 polymorphism Arg399Gln and gastric cancer risk.
|
19034980 |
2008 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase (ADPRT, Val762Ala), 8-oxoguanine DNA glycosylase (OGG1, Ser326Cys) and apurinic/apyrimidinic endonuclease 1 (APE1, Asp148Glu) and evolution of H.pylori-associated precancerous gastric lesions, a population-based cohort study was conducted in Linqu County, a high-risk area of gastric cancer in China.
|
19147860 |
2009 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We additionally found that the variant 399Gln allele in Arg399Gln SNP was associated with a greater risk of developing gastric cancer.
|
27221877 |
2016 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In our association study between three amino acid substitution polymorphisms of XRCC1 (Arg194Trp, Arg280His, and Arg399Gln) and the risk of gastric cancer in the Korean population, none of the polymorphisms were associated with increased risk of gastric cancer.
|
12359351 |
2002 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of the overall meta-analysis did not suggest any association between Arg280His/Arg399Gln polymorphisms and GC susceptibility for all genetic models.
|
21604176 |
2012 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To evaluate the association between polymorphisms XRCC1 Arg194Trp and Arg399Gln and XRCC3 Thr241Met and the risk for chronic gastritis and gastric cancer, in a Southeastern Brazilian population.
|
16425350 |
2005 |